Benzopyrans as openers of potassium channels.

摘要

THE PRESENT INVENTION REFERS TO FORMULA (I) COMPOUNDS AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, WHERE THE INTERMITTENT LINE REPRESENTS AN OPTIONAL COVAL LINK; X IS O, NH, S OR A DIRECT LINK; R {SUP.3} IS HYDROXY WHEN THE INTERMITTENT LINE DOES NOT REPRESENT A COVALENT LINK AND R {SUP.3} IS ABSENT WHEN THE INTERMITTENT LINE REPRESENTS A COVALENT LINK; R {SUP.4} IS (A), WHEN X IS O, A GROUP OF FORMULA (I), (B), WHEN X IS O, NH OS, OPTIONALLY REPLACED BY HYDROXIPHENYL, (C) A 4 TO HETERO CYCLIC RING 7 MEMBERS OPTIONALLY SUBSTITUTED, OR (D), WHEN X IS NH, A GROUP OF FORMULA (II). THE COMPOUNDS ARE USEFUL FOR THE TREATMENT OF DISEASES RELATED TO THE ALTERED TONE OR MOVEMENT OF THE SMOOTH MUSCLE.