N-ACIL-N-HETEROCICLIL-ONAFTALENIL-ALQUIL-AMINOACIDOS AS ANTAGONISTS OF ANGIOTENSIN II.

摘要

THE INVENTION REFERS TO N-ACILO-NHETEROCICLILOALKYL AMINO ACIDS OF THE FORMULA IN WHICH R1 MEANS C1-C7 ALKYL, WHICH IS INSTITUTED OR REPLACED BY HALOGENO OR HYDROXIDE, C3-C7-C7, C7, ALCOXILOC1-C7 OR CICLOALQUILOC3-C7-ALCOXILOC1-C7; R2 IS 1H-TETRAZOLE-5-YL, CARBOXYL, ALCOXYL-CARBONYL-C1-C7, SO3H, PO2H2, PO3H2 OR HALOGEN-C1-C7-ALCANOSULFONYLAMINE; R3 MEANS 1H-TETRAZOLE-5-YL, HYDROXYMETHYL, ALCOXY-METHYL-C1-C7, FORMYL, CARBOXYL, ALCOXY-CARBONYL-C1-C7, C1-C7 ALCOXYLOCARBONYL-C1-C7-C1-C7-C1-C7 -CARBONYL, PHENYL-C1-C4ALCOXYL-CARBONYL OR CARBAMOYLO, WHOSE GROUP AMINO IS UNSUBSTITUTED OR DISSTITUTED BY C1-C7 ALKYL, C1-C7-ALKYNYL, MONO-OR INDEPENDENT ALIENYLE, DISPOSED BY AENILE C2-C7 OR C2-C4-ALKYLENOXYL-C2-C4; ALK METHYLEL, IS ETILEL OR ETILIDEL HET, MEANS (I) IN WHICH Y1 IS INSTEAD OF O, S O N (R) AND R MEANS ALKYLOC1-C7; O MEANS (II) IN WHICH ONE OF THE VARIABLES Y2 AND Y3 IS INSTEAD OF C (R '') AND THE OTHER INSTEAD OF N, OR THE TWO VARIABLES INSTEAD OF C (R ''); Y R '' MEANS HYDROGEN, HALOGEN, ALKYL-C1-C7, ALCOXYL-C1-C7, ALKYNYLOXYL-C2-C7, FELOXYL, BENCILOXYL, TRIFLUOROMETILE O S (O) M, ES, 0, 0 AND R IS HYDROGEN OR ALQUILOU THE INDEX M IS INSTEAD OF 0, 1 OR 2; ONE OF THE X2 AND X4 VARIABLES IS INSTEAD OF RENTS-C1-C4 AND THE OTHER X2 AND X4 VARIABLES ARE INSTEAD OF A LINK; OR THE TWO VARIABLES X2 AND X4 ARE EVERY TIME INSTEAD OF A LINK; X3 MEANS C3-C7-CYCLLOALKYLLIDS OR STRUCTURE ELEMENT C (XA) (XB) IDROGEN OR ALKYL-C1-C7 AND XB IS C1-C7 ALKYL; AND THE RINGS A, B, CYD, UP TO THE SUBSTITUTES INDICATED IN THE FORMULA, AS WELL AS THE AROMATIC SUBSTITUTES, ARE SUBSTITUTED INDEPENDENT BETWEEN OR SUBSTITUTED ONE OR SEVERAL SOME-SELECTED BY A VERY MUCH-COMPUTER GROUP -C1-C7, C2-C7-ALKYNYLOXYL, PHENOXYL, BENZYLOXYL, TRIFLUOROMEYLL AND S (O) MR, WHERE M, IS 0, 1 OR 2; Y R IS HYDROGEN OR ALKYL-C1-C7; AND ITS SALTS; MANUFACTURING METHOD, PHARMACEUTICAL PREPARATIONS CONTAINING A COMBINATION OF FORMULA I OR A SALT OF IT FOR PHARMACEUTICAL EMPLOYMENT, AS WELL AS EMPLOYMENT.