DERIVATIZED COMPLEXES OF DTPA, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AS AN NMR AND X-RAY CONTRAST AGENTS, AND THE PROCEDURE FOR THEIR PREPARATION.

摘要

THE INVENTION REFERS TO COMPLEX COMPOUNDS AND THEIR SALTS CONSISTING OF AT LEAST ONE METAL ION AND ONE AGENT DISPOSING A GENERAL FORMULA (I), WHERE Z {SUP.1} AND Z {SUP.2} REPRESENT INDEPENDENTLY ONE OF ANOTHER ONE HYDROGEN ATOM, THE REST - (CH {SUB.2}) {SUB.M} - C {SUB.6} H {SUB.4}) {SUB.Q} (O) {SUB.K} - (CH {SUB.2}) {SUB.N} - (C {SUB.6} H {SUB.4}) {SUB.1} (O) {SUB.R} - RO EL RESTO - (CH {SUB.2 }) {SUB.M} (C {SUB.6} H {SUB.10}) {SUB.Q} - (O) {SUB.K} - (CH {SUB.2}) {SUB.N} ( C {SUB.6} H {SUB.10} {SUB.1} - (O) {SUB.R} - R, WHERE MYN IS THE NUMBERS 0-5, Q, K, L and R WITH THE NUMBERS 0 OR 1 YS THEY ARE NUMBERS 1 OR 2; R IS A HYDROGEN ATOM, REPLACED IF REQUIRED BY OR {SUP.1} -, REST C {SUB.1} - C {SUB.6} - RENT OF STRAIGHT CHAIN OR BRANCHED CHAIN OR A GROUP CH {SUB.2} COOR {SUP.1}, WHERE R {SUP.1} IS A HYDROGEN ATOM, A REST OF C {SUB.1} - C {SUB.6} - RENT OR A GROUP BENCIL, WITH THE PROVISION THAT ONE OF THE SUBSTITUTES Z {SUP.1} OZ {SUP.2} IS A HYDROGEN ATOM AND THE OTHER IS NOT IT IS, AND THAT IT DOES NOT ALLOW A DIRECT LINK OXYGEN-OXYGEN. THEIR USE IS ALSO DESCRIBED FOR RADIOTHERAPY AND NMR AGENTS AND RADIOGRAPHIC DIAGNOSTIC AGENTS, IN PARTICULAR FOR CONTRACTING OF THE LIVING SYSTEM. A PROCESS FOR THE ELABORATION OF THESE COMPOUNDS AND AGENTS IS ALSO DESCRIBED.