SUBSTANTIALLY ANHYDROUS CRYSTALLINE CEFADROXIL AND METHOD FOR PRODUCING IT

摘要

The invention relates to a substantially anhydrous crystallinecefadroxil having a water content between about 0.8% and 3.9%.Such cefadroxil is obtained slurrying a cefadroxil solvate ofdimethylacetamide, or of N-methyl-2-pyrrolidone or of monomethyl-formamide,with isopropyl alcohol containing either from about2% to 4% of water of from about 0.1% to 4% of water and from 0% toabout 60% of methanol, at a temperature in the range of about +45°Cto +55°C and than filtering the desired cefadroxil so obtained.