ATRIAL HYPOTENSIVE PEPTIDE HAVING 46 AMINO ACIDS

摘要

An atrial natriuretic peptide having profound natriuretic,diuretic and hypotensive effects, characterized by a 46 aminoacid residue sequence:Ser-Gln-Asp-Ser-Ala-Phe-Arg-Ile-Gln-Glu-Arg-Leu-Arg-Asn-Ser-Lys-Met-Ala-His-Ser-Ser-Ser-Cys-Phe-Gly-Gln-Lys-Ile-Asp-Arg-Ile-Gly-Ala-Val-Ser-Arg-Leu-Gly-Cys-Asp-Ile-Leu-Leu-Ile-Ala-Gln,having a disulphide bond between the cysteine residues which maybe extracted from mammalian heart atria is described. Asynthetic 30 amino acid residue peptide corresponding to residues17-46 of the above sequence has also been prepared and shown tohave similar biological activity.