METHOD AND APPARATUS FOR CONTROLLING CONCENTRATIONS IN VIVOS AND IN TUBING SYSTEMS

摘要

A method and apparatus for maximizing the total amount of blood processedduring an apheresis procedure by optimizing the concentration of anticoagulantin a donor/patient and the associated extracorporeal tubing set is provided. Asimplified model of an anticoagulant accumulation in a donor/patient's body isused to calculate an optimal anticoagulant infusion rate profile to thedonor/patient during a blood processing procedure. A maximum acceptableanticoagulant concentration in the donor/patient acts as an upper limit on therate at which anticoagulant may be infused to the donor/patient using theoptimized infusion rate profile. A minimum acceptable anticoagulant level actsas a lower limit in optimally controlling the anticoagulant concentration inthe extracorporeal tubing set. Both the maximum acceptable anticoagulant levelin the donor/patient and the minimum acceptable anticoagulant level in theextracorporeal tubing set may be customized for a specific donor/patientthereby allowing the optimized infusion rate profile and the extracorporealtubing set anticoagulant concentration to be customized for the specificpatient.