Interaction of hla proteins with members of the hsp70 family of proteins

摘要

Present invention based on the identification of the molecular interaction which forms the basis of the immunosuppressive activity of the HLA-B2702.75-84 peptide. Specifically the present invention discloses that the HLA-B2702.75-84 peptide binds to members of the HSP70 family of proteins. Based on this observation, present invention provides methods of identifying agents which can be used to modulate immune system activity.