Stabilized preparations of human troponins and modifications thereof, diagnostic assay methods and assay kits

摘要

Improved assay methods and kits are described for the detection of changes in levels of human troponins in a patient sample, which employ as calibrators either a stable aqueous, acid-dialyzed solution of a troponin protein, the solution having a pH between about 2 and about 5 or lyophilized compositions derived from the aqueous solutions. Also described are modified troponin proteins, fusion proteins and hetero-multimers formed of troponin proteins or functional fragments.