Treatment of infertility and enhancement of fertilization capacity in mammalian males

摘要

The present invention relates to a method for increasing penetration of mammalian ova by mammalian male sperm by contacting sperm in vitro with a penetration-enhancing amount of a penetration-enhancing thymosin polypeptide or a penetration enhancing anti-thymosin antibody. In preferred embodiments, treatment comprises contacting mammalian sperm with thymosin alpha 1 or antibodies to thymosin alpha 1 or thymosin beta 4.