In vitro model for study of the pharmacodynamics of intracellular killing of bacteria and viruses

摘要

Adherent cell lines are grown on cover slips. The cover slips are placed in a culture media containing fluctuating concentrations of drugs for the purpose of testing simulated drug dosage regimens for use in the treatment of human infection. The cover slips are removed and the cells are harvested and processed for viable bacterial numbers of viral DNA over time.