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UNC-53 FROM C. ELEGANS AND ITS USES IN TESTING COMPOUNDS INVOLVED IN THE CONTROL FO CELL BEHAVIOUR AND PHARMACEUTICAL COMPOSITIONS
UNC-53 FROM C. ELEGANS AND ITS USES IN TESTING COMPOUNDS INVOLVED IN THE CONTROL FO CELL BEHAVIOUR AND PHARMACEUTICAL COMPOSITIONS
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机译:C. ELECTANS的UNC-53及其在测试控制细胞行为和药物成分中涉及的化合物中的用途
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摘要
UNC-53 protein of C. elegans or its functional equivalent is identified as a signal transducer/integrator involved in controlling the rate and directionality of cell migration and/or cell shape. Nucleic acid sequences encoding UNC-53 protein or its functional equivalent, such as genomic or cDNA are used to transfect C. elegans or mammalian cell lines useful for identifying inhibitors or enhancers of the UNC-53 protein. Any of the inhibitors or enhancers identified or the UNC-53 protein itself or sequences encoding UNC-53 protein can be used in the preparation of medicament for treatment of neurological conditions such as Alzheimer's or Huntingdon's disease, peripheral neuropathies for inhibition of metastasis.
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