TGF-β FUSION PROTEINS AND THEIR USE IN WOUND HEALING

摘要

A transforming growth factor-β fusion protein and a method of preparation transforming growth factor-β fusion protein. The transforming growth factor-β fusion protein comprises a purification tag, at least one proteinase site, an extracellular matrix binding site, and a transforming growth factor active fragment. A method of preparing transforming growth factor-β fusion protein comprises purifying and renaturing transforming growth factor-β protein to provide an active transforming growth factor-β fusion protein preparation. Methods of use of the transforming growth factor-β fusion protein are also provided.