COLORECTAL CANCER RISK FACTOR DETECTION AND TREATMENT

摘要

Methods of identifying individuals at elevated risk of colon cancer are disclosed. The methods comprise the steps of: detecting a PLA2s gene mutation or an absence of PLA2s protein or PLA2s enzyme activity in a sample from an individual. Methods of preventing colon cancer or reducing risk of colon cancer in an individual who is identifying as being at an elevated risk of colon cancer are disclosed. The methods comprise the steps of identifying an individual predisposed to colon cancer by detecting a PLA2s gene mutation or PLA2s protein or enzyme activity deficiency; and administering to such an individual, a prophylactically effective amount of phospholipase protein or a recombinant vector composing a nucleotide sequence that encodes PLA2s.