ANTIBODIES FOR MODULATING CD47-MEDIATED NEUTROPHIL TRANSMIGRATION

摘要

The present invention relates to methods and compositions for modulating CD47-mediated PMN transmigration across a cell layer. Monoclonal antibodies and functionally active antibody fragments which specifically bind to the CD47 antigen are provided. These antibodies and fragments are useful in screening assays to identify pharmaceutical lead compounds which likewise are capable of modulating CD47-mediated PMN transmigration across a cell layer. Methods and pharmaceutical compositions for modifying the immune response of a subject also are provided. The antibodies and fragments are based upon, or derived from, the C5/D5 antibody having ATCC Accession No. HB-12021.