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METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF PATHOLOGICAL CONDITIONS RELATED TO ABNORMAL DOPAMINE RECEPTOR EXPRESSION
METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF PATHOLOGICAL CONDITIONS RELATED TO ABNORMAL DOPAMINE RECEPTOR EXPRESSION
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机译:诊断和治疗与多巴胺受体异常表达有关的病理状况的方法和组合物
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摘要
Methods and compositions are provided for diagnosing and treating pathological conditions related to a dopamine receptor abnormality. The methods comprise administering to a patient having such a pathological condition a plasmid encoding an oligonucleotide, antisense to one or more RNA molecules encoding one of the several dopamine receptors, thereby selectively controlling expression of one or more dopamine receptor subtypes, and alleviating the pathological conditions related to their expression. The vectors are targeted to specific regions of the brain via complexation with antibody studded liposomes.
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