METHOD FOR PREPARING A PROTEIN SELECTED FROM THE CYTOKINE GROUP, COMPRISING AT LEAST ONE INTRAMOLECULAR DISULPHIDE BOND BY OXIDATION, AT A pH OF LESS THAN 5.0, OF THE REDUCED RECOMBINANT PROTEIN

摘要

process for preparing a protein containing at least one intramolecular disulfide bridge, and, optionally, one or more additional cysteine residues, including the oxidation of the corresponding reduced recombinant protein using an oxidation agent and characterized in that the reaction of aqueous solution of the reduced protein in a ph of less than 5.0.