DRUG DELIVERY PORPHYRIN COMPOSITIONS AND METHODS

摘要

A compound is described having the structure IMAGE where R preferably is IMAGE and most preferably R3 is a closo-carborane and R2 is -H, an alkyl or aryl having 1 to about 7 carbon atoms, or a physiologically acceptable salt. Compounds of the invention are useful in boron neutron capture therapy, photodynamic therapy, and other biomedical applications. One embodiment we have designated 2,4-bis-[ alpha , beta -(1,2-dicarbaclosododecaborane carboxy)ethyl]deuteroporphyrin (x), appears not to pass through the normal blood brain barrier, has excellent water solubility, and has been shown efficacious in boron neutron capture therapy in vivo against the KHJJ mammary carcinoma.