GENETICALLY ENGINEERED MICE CONTAINING ALTERATIONS IN THE MHC CLASS II GENES.

摘要

the invention relates to mice deficient in the normal expression of one or more genes of the major histocompatibility complex class ii mice heterozygous able to present such a disability, as well as cell lines, preferential the pluripotent cell lines or totipotent, which are heterozygous.homozygous or chimeric and able to make such a disability, as well as to their use, particularly in situations where the absence of at least one gene of the major histocompatibility complex and its normal expression is desired.