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A 24 KILODALTON CYTOPLASMIC PROTEASE ACTIVATING DNA FRAGMENTATION APOPTOSIS
A 24 KILODALTON CYTOPLASMIC PROTEASE ACTIVATING DNA FRAGMENTATION APOPTOSIS
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机译:24 KILODALTON胞浆蛋白酶激活DNA片段凋亡
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摘要
An apoptosis-associated protease having a relative mass of 24 kilodaltons and a defined amino acid composition is disclosed, together with a method for its purification from a cytoplasmic extract of mammalian cells treated with an apoptosis-inducing agent, such as tumor necrosis factor- alpha or UV irradiation, that comprises affinity chromatography with the serine protease inhibitor DK120 followed by heparin-sepharose chromatography. The protease has activity against the elastase-like substrate MAAPV and is capable of inducing apoptosis in isolated U937 cell target nuclei.
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