HETEROCYCLIC COMPOUNDS, USEFUL AS ALLOSTERIC EFFECTORS AT MUSCARINIC RECEPTORS USEFUL AS ALLOSERIC EFFECT IN MUSCARIN SINGLE RECEPTORS

摘要

The compounds of formula (I) and their pharmaceutically acceptable salts and esters thereof are allosteric effectors at muscarinic receptors and are useful for the treatment and prevention of diseases associated with muscarinic receptors:;(Wherein Z is a methylene group, a methine group, a formula NH or a formula = N- group, W is a methylene group, a methine group, a sulfur atom or a group represented by the formula S (O) v wherein v is 1 or 2 ) And if W is a group of formula S (O) v then Z is not a group of formula NH; Each Ao represents a double bond to turn a single bond, Y ^1, Y ^2, Y ³ and Y ⁴ in at least one is a carboxyl group, a protected carboxyl group, a sulfonamide group, a protected sulfonamide group or a group represented by the formula - (A) pB ¹ -T ¹ wherein A is an oxygen atom or a sulfur atom, T ¹ is a carboxyl group, a thiocarboxy group, a dithiocarboxy group, a protected carboxyl group, a protected thiocarboxy group, a protected dithiocarboxy group, A tetrazolyl group, B1 is a direct bond, an alkylene group which may be substituted, and p is 0 or 1; The groups Y ¹ , Y ² , Y ³ and Y ⁴ which are not defined hereinbefore may be the same or different and are each a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a thiol group, an amino group, An alkylthio group, an alkylsulfinyl group, an alkylsulfonyl group, an aryl group, an aralkyloxy group, an aralkylthio group, Y ¹ may together with Y ² represent a lactone group or a keto group; R a ¹ and R ² are a hydrogen atom, an alkyl group, an alkanoyl group, an aralkyl group, an aralkyl group, an aralkyl group, a carboxyl group, a protected carboxyl group, a sulfonamide group, a protected sulfonamide group, or a group represented by the formula - (O) qB ² -T ² group (wherein, T ² is a carboxyl group, a protected carboxyl group, a sulfonamide group, a protected sulfonamide group, or a tetrazolyl group, B ² is an alkylene group or an amino group, a protected amino group, hydroxyl group protection and And q is 0 or 1; and R 2 is an alkylene group having at least one substituent selected from a hydrogen atom, The other of R ¹ and R ² is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an aryl group or an aralkyl group, or the other of R ¹ and R ² is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, An aralkyl group, or R ¹ and R ² together form a group of the formula (Ib '):;Wherein R ¹⁰ , R ¹¹ and R ¹² are the same or different and each represents a hydrogen atom, a hydroxyl group, a halogen atom, a haloalkyl group, an alkyl group, an alkyl group which may be substituted, an alkoxy group, an alkylthio group, , An alkylsulfonyl group; R ³ is a hydrogen atom or an amino protecting group.