Weight modulators corresponding to nucleic acids and fats, and diagnostic and therapeutic uses thereof (MODULATORS OF BODY WEIGHT, CORRESPONDING NUCLEIC ACIDS AND PROTEINS, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF)

摘要

The present invention relates generally to the weight control of animals, including mammals and humans, and in particular, the presently disclosed subject matter relates to diagnosis and therapy as a body weight regulator and to the use of such modulators. In its broadest aspect, the present invention relates to the identification and presentation of nucleic acids and proteins that exhibit the function of the mammalian body weight regulator that is presumably due to the nucleic acid sequence and the nucleic acid or their degradation variability. The nucleic acid sequence of interest represents a gene corresponding to the mouse and human OB genes, which are considered to play a dramatic role in controlling body weight and fat accumulation. The first data presents a polypeptide product of a gene of questionable function, such as hormone. Also provided are nucleic acid molecules for use as molecular probes or for polymerase chain reaction amplification, i. E. As primers, such as synthetic or natural oligonucleotides. The present invention also provides an asexual vector comprising a nucleic acid molecule of the present invention operatively associated with a nucleic acid and a bacterial, insect, or mammalian expression vector, a labeled control sequence of the present invention. Accordingly, the present invention relates to bacterial or mammalian cells that have been infectious or transformed with a suitable labeling vector, and, in particular, the use of such structures during the preparation of the modulators of the invention. It also provides antibodies against OB polypeptides. Methods of controlling the weight of mammals, providing both isoform gene encoding of both mouse and human OB polapeptides.