Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus

摘要

The present invention relates to a peptide comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus in humans. More specifically, the present invention relates to seven peptide groups comprising epitopes of human 60kDa Ro / SSA antigens and four peptide groups comprising epitopes of 52kDa Ro / SSA antigens and their systemic lupus erythematosus. It relates to the use as a diagnostic kit.;The above-described peptide group of the present invention actually functions as an epitope of 60kDa and 52kDa Ro / SSA antigens through ELISA analysis using serum collected from patients with systemic lupus erythematosus, and can be used for diagnosis of systemic lupus erythematosus. It turns out that. Therefore, even without the entire protein of 60kDa and 52kDa Ro / SSA antigen, it is possible to diagnose systemic lupus erythematosus using only the peptide of the present invention. Can be prepared. In addition, the peptides of the invention can be used to produce anti-60kDa and 52kDa Ro / SSA sources.