a-anilated pyrrole derivatives and their pharmacological uses (a-Annelated Pyrrole Derivatives and Pharmaceutical Use Thereof)

摘要

The present invention relates to a heterocyclic compound represented by the following formula (I).;In this formula, the radicals R RTI ID = 0.0 ^One, R²And R³2 is H, or is optionally halogen, pseudohalogen, CF₃, NO₂, OH, alkoxy, OCF₃Alkyl, and aryloxy, or is an aryl radical having one or more oxygen, nitrogen and / or sulfur atoms, optionally condensed with a phenyl or naphthyl radical, optionally substituted with halogen, CF₃, A 1 or 2 ring aromatic heterocyclic radical substituted by alkyl or alkoxy; Radical R^One, R²And R³The other is H, CHO, CO₂H, COO alkyl, COS alkyl, COCO₂H, COCO₂Alkyl or A-Y, wherein A is C_One-C₈Alkylene or C₂-C₈Alkenylene, Y is CO₂H, CO, OPO (OH)₂, OP (OH)₂, Acid type groups, COO alkyl, SO₂O alkyl, CHO, OH, or CONR⁸R⁹; Wherein R⁸And R⁹May be the same or different and are H, alkyl, OH, acyl, SO₂Alkyl, or SO₂Phenyl, the alkyl radical of the sulfonyl group is optionally substituted with one or more halogen atoms, the aryl radical optionally substituted with one or more halogens, C_One-C₈Alkyl or C_One-C₈Alkoxy radical; R⁴, R⁵, R⁶And R⁷May be the same or different and represent H, alkyl, Y, or AY according to the definition above, and two of the adjacent radicals represent a chemical bond between the two ring atoms to which they are attached and the other two are as defined above , Or two of the superimposed radicals together with the carbon atoms to which they are attached represent a carbonyl group or a thio analog thereof; X is O, S, SO, SO₂, CO, or NR¹⁰, Wherein R¹⁰/RTI is H, or optionally halogen, C_One-C₈Alkyl or C_One-C₈Alkyl substituted with alkoxy, A-Y according to the definition above, or aryl, and B is CR¹¹R¹²(Wherein R¹¹And R¹²May be the same or different). H, alkyl, Y, or A-Y according to the definition above, or R¹¹And R¹²Or a carbonyl group or a thio group thereof, and a is 0, 1 or 2;;The compounds are useful for the treatment of diseases of the rheumatic group and for the prevention of allergic diseases.