首页> 外国专利> Guanidinomethyl cyclohexane carboxylic ester derivative RTI ID = 0.0 (Guanidinomethyl cyclohexane / RTI amp;

Guanidinomethyl cyclohexane carboxylic ester derivative RTI ID = 0.0 (Guanidinomethyl cyclohexane / RTI amp;

机译:胍基甲基环己烷羧酸酯衍生物(胍基甲基环己烷

摘要

The present invention relates to a compound represented by the formula (I-2) or a pharmaceutically acceptable acid addition salt thereof.;Ar represents a halogen atom, a cyano group, a nitro group, a carboxyl group, an alkyl group having 1 to 18 carbon atoms, an alkoxy group having 1 to 18 carbon atoms, a cycloalkyl group having 3 to 18 carbon atoms, an aralkyl group having 7 to 18 carbon atoms, An arylalkyloxy group having 7 to 18 carbon atoms, a phenoxy group which may have a substituent, an alkoxycarbonyl group having 2 to 19 carbon atoms which may have a substituent, an aralkyl group having 8 to 19 carbon atoms which may have a substituent A phenyl group, a biphenyl group or a naphthyl group having at least one substituent selected from the group consisting of an alkyloxycarbonyl group. Provided that Ar is substituted with a halogen atom, a cyano group, a nitro group, a carboxyl group, an alkyl group having 1 to 18 carbon atoms, an alkoxycarbonyl group having 2 to 19 carbon atoms which may have a substituent, or an aralkyloxycarbonyl group having 8 to 19 carbon atoms Except for the case of a phenyl group.;The compound or a pharmaceutically acceptable acid addition salt thereof is useful as an antibacterial agent against Helicobacter pylori and a pharmaceutical composition for treating Helicobacter pylol infection.
机译:本发明涉及由式(I-2)表示的化合物或其药学上可接受的酸加成盐。Ar表示卤素原子,氰基,硝基,羧基,具有1至1的烷基。 18个碳原子,1〜18个碳原子的烷氧基,3〜18个碳原子的环烷基,7〜18个碳原子的芳烷基,7〜18个碳原子的芳烷基氧基,苯氧基。取代基,可具有取代基的碳原子数为2〜19的烷氧基羰基,可具有取代基的碳原子数为8〜19的芳烷基。苯基,联苯基或萘基中的至少一种选自以下。由烷氧基羰基组成的基团。只要Ar被卤素原子,氰基,硝基,羧基,具有1至18个碳原子的烷基,可以具有取代基的具有2至19个碳原子的烷氧羰基或芳烷氧基羰基取代,具有8至19个碳原子的基团;除了苯基的情况外;该化合物或其药学上可接受的酸加成盐可用作针对幽门螺杆菌的抗菌剂和用于治疗幽门螺杆菌感染的药物组合物。

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