Taxol and its derivatives (Method for preparation of taxol and its derivatives)

摘要

The present invention relates to a process for the preparation of a compound of formula (I) which comprises a process for the reaction of a compound of formula (II) with a compound of formula (III) in the presence of a condensing agent to give a compound of formula (IV) .;Wherein R ₁ is an aryl or heteroaryl group, R ₂ is hydrogen, arylcarbonyl, heteroarylcarbonyl or C ₁ -C ₆ alkoxycarbonyl, and R ₃ is selected from the group consisting of hydrogen Or acetyl, and R ₈ and R ₉ are each independently a hydroxy protecting group.