LIVE RECOMBINANT VACCINE OF HEPATITIS B BASED ON SMALLPOX VIRUS FOR ORAL USE AND METHOD OF ITS PREPARING

摘要

FIELD: medicine, virology. SUBSTANCE: vaccine - tablets coated with protective acid-resistant shell that consist of recombinant smallpox virus expressing preS2-Ag and HBs-Ag and vehicle (lactose, sucrose, vanillin, calcium stearate). Use of this preparation ensures to increase safety and effectiveness of hepatitis B and smallpox specific prophylaxis. EFFECT: enhanced effectiveness of vaccine. 2 cl, 1 tbl