NON-POROUS MICROSPHERES ADAPTED FOR PARENTERAL ADMINISTRATION, METHOD FOR PREPARING SAME AND SUSPENSION BASED ON SAID MICROSPHERES

摘要

FIELD: medicine. SUBSTANCE: proposed solid non-porous sustained-effect microspheres have diameter 5-300 mcm and contain at least one pharmaceutically active substance enclosed into spherical envelope formed by at least one pharmaceutically inert carrier substance. Latter is naturally present in recipient's organism, remains stable in solid state up to at least 60 C, and is dissolved by recipient physiological medium at slower pace than pharmaceutically active principle. Proposed method for preparing said microspheres comprises following steps of: melting down pharmaceutically inert carrier substance, dispersing pharmaceutically active principle into melt in inert atmosphere, pulverizing dispersion thus-obtained in form of mist in freezing chamber under pressure in inert atmosphere at temperatures ranging from -15 C up to -50 C, separating resultant microspheres into fractions according to their sizes. Proposed suspension intended for administration by parenteral injection comprises effective amount of said microspheres distributed in pharmaceutically acceptable liquid vehicle, said pharmaceutically active principle being insoluble in said liquid vehicle. EFFECT: novel microspheres make it possible to retard and prolong curative effect of active agents which are too fast dissolved in physiological medium agents acting upon central or vegetative nervous system, such as vasodilative and antihistaminic agents, hormones, contraceptives. 16 cl, 13 dwg