DNA molecules stabilised by modifications to the 3'-TERMINAL PHOSPHODISE binding, their use as nucleic acid species and as a THERAPEUTICAL agent to inhibit the expression of specific objectives

摘要

The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.