lymphoides cd30 antigen

摘要

PCT No. PCT/DE92/00956 Sec. 371 Date Sep. 8, 1994 Sec. 102(e) Date Sep. 8, 1994 PCT Filed Nov. 16, 1992 PCT Pub. No. WO93/10232 PCT Pub. Date May 27, 1993The description relates to the lymphoid surface antigen CD30 (Ki-1) occurring in Hodgkin's disease, the protein sequence and the associated nucleotide sequence therein, manufacture thereof by genetic engineering, methods for diagnosis and investigation of Hodgkin's disease and use of these nucleotide sequences for producing transgenic animals. The invention provides methods not based on monoclonal antibodies for investigation and diagnosis of anaplastic large-cell lymphomas.