NEW ACYCLICAL AMIDING GROUP-CONTAINING DIPHOSPHONIC ACID DERIVATIVES, MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH RELEASE AND RELATIONS

摘要

PCT No. PCT/EP93/01833 Sec. 371 Date Mar. 28, 1995 Sec. 102(e) Date Mar. 28, 1995 PCT Filed Jul. 13, 1993 PCT Pub. No. WO94/02492 PCT Pub. Date Feb. 3, 1994Compounds of the formula I IMAGE (I) in which R1 signifies hydrogen, a straight-chained, branched, saturated or unsaturated alkyl radical with 1-9 carbon atoms possibly substituted by phenyl or a phenyl ring which is possibly substituted by C1-C3alkyl, C1-C3-alkoxy or halogen, R2 signifies hydrogen or C1-C3-alkyl, whereby the two radicals can be the same or different, R represents hydrogen or a straight-chained or branched alkyl radical with 1-4 carbon atoms, X signifies an alkylene chain with 1-6 carbon atoms which can be substituted one or more times by C1-C3-alkyl and can possibly be interrupted by oxygen, whereby 1 or 2 carbon stems of the alkylene chain can possibly be part of a cyclopentyl or cyclohexyl ring and Y signifies hydrogen, hydroxyl or amino group possibly substituted by alkyl groups with 1-6 carbon atoms, as well as their pharmacologically acceptable salts, processes for their preparation, as well as medicaments for the treatment of calcium metabolism disturbances.