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transdermal therapeutic system for the administration of naloxone
transdermal therapeutic system for the administration of naloxone
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机译:纳洛酮的经皮治疗系统
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摘要
Transdermal therapeutic system comprises: (i) a release liner of siliconised poly(ethylene terephthalate) (PET) or other suitable material; (ii) an acrylate-based adhesive including 0.2-2 mg/sq.cm. of naloxone (1-N-allyl-7,8-dihydro-14-hydroxynormorphinone)hydrochloride (I) and enough alkali hydroxide (e.g., NaOH or KOH) to give the polymer soln. during the prepn. a pH of 7.2-8.7; and (iii) a backing foil of PET or other suitable material.
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