20,21-Dinoreburnamine derivatives substituted in position 15, process for their preparation and the intermediate compounds thus obtained, their use as medicaments and compositions containing them

摘要

The products of formula (I): IMAGE in which X1, X2 and X3, which may be identical or different, represent a hydrogen atom, a halogen atom, an alkyl, alkenyl or alkynyl radical containing at most 18 carbon atoms and optionally substituted, an alkoxy radical containing at most 7 carbon atoms and optionally substituted, a hydroxyl, trifluoromethyl or nitro radical, an amino or mono- or dialkylamino radical or an optionally substituted phenyl radical, and in which IMAGE represents A) either the group IMAGE in which A represents: a) an alkyl, alkenyl or alkynyl radical containing at most 7 carbon atoms and optionally substituted, b) an optionally substituted phenyl radical; B) or the group IMAGE in which R1 represents one of the two groups IMAGE in which one of the radicals R8 and R9 represents a hydrogen atom, an alkyl, alkenyl or alkynyl radical containing at most 6 carbon atoms and optionally substituted, an optionally substituted phenyl radical, an esterified carboxyl radical, a cyano radical or an acyl radical having from 2 to 6 carbon atoms, and the other of the radicals R8 and R9 represents a hydrogen atom, an alkyl, alkenyl or alkynyl radical containing at most 6 carbon atoms and optionally substituted or an optionally substituted phenyl radical, and R10 represents a hydrogen atom, an alkyl, alkenyl or alkynyl radical containing at most 5 carbon atoms and optionally substituted, or an optionally substituted phenyl radical. These products possess advantageous pharmacological properties which justify their use as medicaments.