A method for obtaining klavulinsäure and their pharmaceutically acceptable salts of fermentation cultures of streptomyces sp.

摘要

A NEW METHOD FOR OBTAINING ACID Z (2R, 5R) -3- (2-hydroxyethylidene) -7-oxo-4-OXA-1-azabicyclo (3,2,0) -heptane-2-carboxylic acid and salts and pharmaceutically acceptable esters thereof, from fermentation broths of Streptomyces SP. Comprising: (A) flocculation hotbed using as an electrolyte coagulant INORGANIC WITH ORGANIC AS polyelectrolyte flocculating aid; (B) Purification of said acid in the culture broth, flocculated and decanting ONCE, FOR FORMATION AS STABLE INTERMEDIATE PRODUCTS, salts derived from primary amines, secondary and tertiary; (C) forming pharmaceutically acceptable salts ACTIVE. Said novel process has EARNINGS PER YOUR FACE Inhibitory Activity lactamases SYNERGISTIC EFFECT AND MARKING WHEN associated with other lactam antibiotics TYPE penicillins and cephalosporins.