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UNITAL GALENIC FORM FOR LOCAL HORMONOTHERAPY OF VAGINAL DROUGHT
UNITAL GALENIC FORM FOR LOCAL HORMONOTHERAPY OF VAGINAL DROUGHT
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机译:局部阴道激素治疗的单一盖乐氏形式
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摘要
This galenical form in intended to a local treatment, essentially non systemic, of the vaginal dryness, particularly in menopaused women. It comprises a free natural oestrogen, particularly in micronized or vectorized, selected amongst 17 beta -estradiol and its salts in solution or in suspension in a lipophilic agent, with an oestrogen contents corresponding to a unit dose equivalent to 15 mu g at the most, preferably less than 10 mu g of 17 beta estradiol, a bioadhesive gelifying hydrophilic agent, a gelifying agent of the lipophilic agent and a hydrodispersible agent. It comprises on the one hand, in the form of a soft capsule, an external solid hard or soft envelope containing gelatine and glycerin and, on the other hand, a liquid or semi-liquid internal phase containing the lipophilic agent with the oestrogen in solution or in suspension, the bioadhesion agent and the gelifying hydrophilic agent of the lipophilic agent. In a sustained release ovule form, it comprises a solid hard or semi-soft non aqueous homogeneous phase containing the lipophilic agent with the oestrogen in solution or in suspension, the hydrophilic bioadhesive gelifying agent, the gelifying agent of the lipophilic agent and the hydrodispersible agent.
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