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Cloning of the biosynthetic pathway for chlortetracycline and tetracycline formation and cosmids useful therein
Cloning of the biosynthetic pathway for chlortetracycline and tetracycline formation and cosmids useful therein
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机译:克隆金霉素和四环素形成的生物合成途径以及其中有用的粘粒
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摘要
The present invention describes a purified and isolated nucleic acid molecule which encodes for the biosynthetic pathway of tetracycline, chlortetracycline or an analogue thereof. The invention relates to the isolation and cloning of the nucleic acid molecule in an isolated fragment from Streptomyces aureofaciens and the expression of the biosynthetic gene in a heterologous host such as Streptomyces lividans.
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