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Immunoassay for tetrachloroisophthalonitrile (chlorothalonil), its derivatives and breakdown products
Immunoassay for tetrachloroisophthalonitrile (chlorothalonil), its derivatives and breakdown products
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机译:四氯间苯二甲腈(百菌清),其衍生物和分解产物的免疫分析
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摘要
Novel derivatives of chlorothalanil® (tetrachloroisophthalonitrile, TCPN), permit conjugation of the TCPN derivative to a carrier useful as an immunogen to induce antibodies specific for TCPN or a TCPN metabolite, or a screening antigen to detect such antibodies. Polyclonal and monoclonal antibodies specific for TCPN or a TCPN metabolite, as well as hybridoma cells producing such antibodies are disclosed. Also provided are immunoassay methods for detection and quantitation of pesticide chemicals, in particular, the fungicide TCPN or a TCPN metabolite, and kits containing a TCPN derivative screening antigen, an anti-TCPN or anti- TCPN metabolite antibody useful for performing the immunoassays.
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