Process for the preparation of cellulose based chiral separation liquid chromatography stationary phase

摘要

A process for preparing a cellulose ester liquid chromatographic stationary phase by reacting cellulose with an aromatic acid halide, such as p-toluoyl chloride, in the presence of a base catalyst, such as pyridine, the reaction temperature and the concentration of base catalyst being below the temperature and concentration at which the cellulose ester dissolves, the reaction time being less than the reaction time at which the cellulose ester dissolves. Similarly, a process for preparing a cellulose carbamate liquid chromatographic stationary phase by reacting cellulose with an aromatic isocyanate, such as 3,5-dimethyl phenyl isocyanate, in the presence of a base catalyst, such as pyridine, the reaction temperature and the concentration of base catalyst being below the temperature and concentration at which the cellulose carbamate dissolves, the reaction time being less than the reaction time at which the cellulose carbamate dissolves.