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In inhibition of G protein function and disposal of vegetating disease useful tricyclic chemical compound
In inhibition of G protein function and disposal of vegetating disease useful tricyclic chemical compound
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机译：在抑制G蛋白功能和治疗植物病方面有用的三环化合物
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摘要
A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a novel compound of the formula (Ia), (Ib) or (Ic) IMAGE (Ia) IMAGE (Ib) IMAGE (Ic) wherein: R and R1 are H, alkyl, halogeno, OH, alkoxy, NH2, alkylamino, dialkylamino, CF3, SO3H, CO2R3, NO2, SO2NH2, or CONHR4; n is 0 or 1; R2 is a group of the formula R5C(O)-, R5CH2C(O)-, R5C(R6)2C(O)-, R5SO2-, R5CH2SO2-, R5SCH2C(O)-, R5OC(O)-, R5NHC(O)-, R5C(O)C(O)- or R5SC(O)-; R5 is alkyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl or heterocycloalkyl; and R6 is alkyl or C(R6)2 is a carbocyclic ring; or pharmaceutically acceptable salts thereof.
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机译：公开了一种抑制Ras功能并因此抑制细胞生长的方法。该方法包括给予式（Ia），（Ib）或（Ic）的新化合物（Ia）（Ib）（Ic），其中：R和R 1为H，烷基，卤代，OH，烷氧基，NH2，烷基氨基，二烷基氨基，CF3，SO3H，CO2R3，NO2，SO2NH2或CONHR4; n为0或1; R 2为式R5C（O）-，R5CH2C（O）-，R5C（R6）2C（O）-，R5SO2-，R5CH2SO2-，R5SCH2C（O）-，R5OC（O）-，R5NHC（O）的基团）-，R5C（O）C（O）-或R5SC（O）-; R5是烷基，芳基，芳基烷基，芳基烯基，杂芳基，杂芳基烷基，杂芳基烯基或杂环烷基; R6为烷基或C（R6）2为碳环;或其药学上可接受的盐。
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