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Multipurpose Characteristic main stem of person and nonhuman Primates, system for maintaining, breeding and differentiation the precursive and the maturity marrow cell
Multipurpose Characteristic main stem of person and nonhuman Primates, system for maintaining, breeding and differentiation the precursive and the maturity marrow cell
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机译:人和非人灵长类动物的多用途特征性主要茎,维持,繁殖和分化前体细胞和成熟骨髓细胞的系统
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摘要
The present invention relates to a method of engrafting human or non-human primate pluripotent stem cells, such as CD34+ cells, in a mouse. The method comprises administering to irradiated mice immortalized human or non-human primate bone marrow stromal cells which express cytokines supporting growth of cells, such as CD34+ cells, and, sequentially or simultaneously, administering purified human or non-human primate CD34+ cells. The stromal cells and CD34+ cells can be administered by intraperitoneal or intravenous injections. The invention can be used to evaluate gene therapy protocols for human CD34+ cells as well as having applications in the treatment of patients exposed to irradiation such as during a bone marrow transplant. The invention also provides an animal model for the study of human hematopoiesis.
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