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Novel process for the preparation of new nucleoside 2'-known and by intramolecular nucleophilic substitution
Novel process for the preparation of new nucleoside 2'-known and by intramolecular nucleophilic substitution
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机译:制备新的已知核苷2'并通过分子内亲核取代的新方法
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PCT No. PCT/US95/06641 Sec. 371 Date Oct. 30, 1996 Sec. 102(e) Date Oct. 30, 1996 PCT Filed May 25, 1995 PCT Pub. No. WO95/35102 PCT Pub. Date Dec. 28, 1995A method for the preparation of 2'-modified nucleosides is provided. The method comprises a novel intramolecular nucleophilic displacement reaction. Included in the invention are novel 2'-modified pyrimidines and purines prepared according to the method of the invention, novel pyrimidines and purines bearing a 2',3' heterocyclic substituent and oligonucleotides containing said 2'-modified pyrimidines and purines. The 2'-modified nucleosides are useful as anti-viral and anti-neoplastic agents.
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