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The butylene oxide - ethylene oxide block copolymer surface active agent as a stabilizer coat for the minute crystal formulation
The butylene oxide - ethylene oxide block copolymer surface active agent as a stabilizer coat for the minute crystal formulation
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机译:环氧丁烷-环氧乙烷嵌段共聚物表面活性剂作为微晶配方的稳定剂涂层
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摘要
This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface thereof, the surfactant being a block copolymer of ethylene oxide and butylene oxide and a method of making such nanoparticles. The compositions exhibit reduced macrophage uptake and improved toxicological profiles and facilitate particle size reduction such that milling time can be reduced and/or sterile filtration of the nanoparticles can be accomplished.
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