Action enhancing agent of nerve growth factor containing 1,2-ethanediol derivative or its salt

摘要

General formula [i]In formula (R1), R1 may be substituted, phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl or heterocyclic groups; R2 is a hydrogen atom or a lower alkyl group or hydroxyl protecting group; R3 is a hydrogen atom or a lower Al The alkyl group; n R4 and R5 each have the same or different hydrogen atoms or lower alkyl groups; R6 may be substituted for amino or nitrogen containing heterocyclic or ammonoio groups; and N represents an integer of 0 to 6, respectively. 1,2-ethanediol derivatives or their salts have an enhanced effect of NGF action, and various diseases caused by degeneration of the central nervous system and peripheral nervous system, such as Alzheimer's disease, Huntington's disease, various neuropathy and Reye de It is useful as a therapeutic drug such as y syndrome, traumatic neuropathy, amyotrophic lateral sclerosis (ALS).