ASYMMETRIC WACKER TYPE CYCLIZING REACTION USING PALLADIUM COMPLEX CATALYST

摘要

PROBLEM TO BE SOLVED: To obtain a new complex, comprising an optically active biaryl type oxazoline-palladium complex having axial asymmetry and useful as a catalyst, for an asymmetric Wacker type cyclizing reaction capable of efficiently providing an optically active heterocyclic compound from olefin compounds. ;SOLUTION: This new optically active biaryl type oxazoline-palladium complex having the axial asymmetry is represented by formula I [A¹ to A⁴ are each H, a 1-6C (substituted)alkyl, a 2-6C (substituted)alkenyl, a 1-6C (substituted) alkoxy, cyano, nitro, a halogen, etc.; A³ and A⁴, together with the benzene ring to which they are bonded, may form a naphthyl ring; W¹ and W² are each H (not simultaneously H), a 1-6C (substituted)alkyl, a (substituted)phenyl, a (substituted)benzyl, etc.; X is acetoxy, trifluoroacetic acid, a halogen, etc.; *stands for asymmetric carbon] and is useful as a catalyst, etc., for an asymmetric Wacker type cyclizating reaction. The complex is obtained by reacting binaphthyloxazoline compound represented by formula II, etc., with bis(acetonitrile)palladium(II) chloride, etc., in a solvent.;COPYRIGHT: (C)1998,JPO