NEW IMIDAZOLE DERIVATIVE HAVING ORTHOMETHOXYPHENYLPIPERAZINYLALKOXYARYL GROUP AND ITS PRODUCTION

摘要

PROBLEM TO BE SOLVED: To obtain a new imidazole derivative having both an angiotensin II-antagonizing action and an α₁-blocking action, and useful as a therapeutic medicine for circulatory diseases such as hypertension, cardiac diseases (cardiac hypertrophy, cardiac failure, etc.), nephritis and apoplexy. ;SOLUTION: An imidazole derivative of formula I [A is methylene, carbonyl; R is a 1-3C lower alkyl, a 1-5C acyl; X is CH, N atom; Y is carboxy, tetrazole; (m) is 0, 1; (n) is 3, 4] or its pharmaceutically acceptable salt. For example, 4-[3-[4-[[2-butyl-4-chloro-1-[(2'-ethoxycarbonylbiphenyl-4-yl)methyl]imidazol-5- yl]methylaminomethyl]phenoxy]propyl]-1-(2-methoxyphenyl)piperazine. The compound of formula I (Y is carboxy group) can be obtained by hydrolyzing a compound of formula II (R¹ is a 1-3C lower alkyl).;COPYRIGHT: (C)1997,JPO