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PRODUCTION OF PHYTONE AND ISOPHYTOL

机译:植脂和异植醇的生产

摘要

PROBLEM TO BE SOLVED: To industrially and advantageously produce the subject compound useful as a synthetic raw material for biologically active substances such as vitamin E by efficiently and simply producing 6-methyl-2-heptanone from isovaleral and acetone and using the compound as a raw material. SOLUTION: Isovaleral is subjected to cross aldol condensation with acetone while continuously each adding isovaleral and an aqueous alkali solution to acetone to form 6-methyl-3-hepten-2-one and the compound is hydrogenated to form 6-methyl-2-heptanone and 6-methyl-2-heptanone is used as a raw material to finally form 6,10,14-trimethyl-5,9-pentadecadien-2-one, which is then hydrogenated to provide the objective phytone and the phytone is further reacted with a Grignard reagent to vinylate or ethynylate the phytone and the treated phytone is partially hydrogenated to provide the objective isophytol.
机译:解决的问题:通过有效和简单地从异戊醛和丙酮生产6-甲基-2-庚酮并使用该化合物作为原料,在工业上有利地生产用作生物活性物质(如维生素E)合成原料的主题化合物材料。解决方案:将异戊醛与丙酮进行交叉羟醛缩合,同时连续向丙酮中分别添加等价戊烷和碱水溶液,以形成6-甲基-3-庚二酮,然后将化合物氢化以形成6-甲基-2-庚酮。以6-甲基-2-庚酮为原料,最终形成6,10,14-三甲基-5,9-十五碳二烯-2-酮,然后进行氢化生成目标植酮,使植酮进一步反应用格氏试剂对植酮进行乙烯基化或乙炔化,然后将处理过的植酮部分氢化以提供目标异植醇。

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