AMPHIPHATIC CHITOSAN DERIVATIVE AND SKIN PREPARATION FOR EXTERNAL USE CONTAINING THE SAME

摘要

PROBLEM TO BE SOLVED: To obtain a novel amphiphatic chitosan derivative that has sufficient amphiphatic properties, can be suitably used as a dispersion stabilizer or emulsifier in a skin preparation for external use and can be expected to have safe antimicrobial and moisturizing properties. ;SOLUTION: An N-acylamino saccharide represented by formula I (R is a 2-22C alkyl; X is a saccharide; Y is chitosan, partially deacetylated chitin; n is an integer of 1 or more) is introduced to an amino group, or an N- alkylaminosaccharide or N-alkenylaminosaccharide of formula II is introduced to the amino group, or a sugar ester of formula III is introduced to the amino group to give the objective amphiphatic chitosan derivative, for example, a compound of formula IV (m, n are each an integer of 1 or more where m+n=60-65 and n (m+n)=0.68). The compounds of formulas I-III are prepared by introducing an N-acylaminosaccharide, an N-alkylaminosaccharide, an N- alkenylaminosaccharide or a sugar ester to the amino group in chitosan or partially deacetylated chitin.;COPYRIGHT: (C)1998,JPO