PREPARATION FOR TRANS-LUNG ADMINISTRATION CONTAINING HYALURONIC ACID

摘要

PROBLEM TO BE SOLVED: To obtain the subject preparation for trans-lung administration, in which peptidic drugs are formulated with hyaluronic acid and by which the absorption of the peptidic drugs, particularly insulin, into the body system is significantly increased and the drugs are stabilized. ;SOLUTION: This method for preparation is carried out by dissolving an peptidic drug (e.g. human insulin or the like) into an isotonic phosphoric acid buffer brine (pH7.0) to prepare an aqueous solution of the peptidic drug and then by dissolving sodium hyaluronate into this aqueous solution, so that the solution finally becomes in a concentration of 0.075-0.125wt.%, to form an objective preparation for trans-lung administration, by which a dosage form capable of significantly increasing absorption of the peptidic drug, particularly insulin, into the body system is given and the drug in the preparation can be stabilized.;COPYRIGHT: (C)1997,JPO