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New and loss tang 17 carboxylic acid ester, the manufacturing method and includes that the medicine
New and loss tang 17 carboxylic acid ester, the manufacturing method and includes that the medicine
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机译:新型损耗糖17羧酸酯,药物的制造方法和包括
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摘要
The invention relates to androstane-17-carboxylic acid esters, represented by general formula (I): IMAGE wherein R1 represents a lower alkyl group containing 1 to 4 carbon atoms, a lower alkyl group containing 2 to 4 carbon atoms substituted by an amino group, or an aralkyl group from 6 to 12 carbon atoms, R2 and R3, which may be the same or different, represent a hydrogen atom or a lower alkyl group containing 1 to 4 carbon atoms, R4 represents a hydrogen atom, a hydroxy group or an acetoxy group, R5 represents a hydroxy or acetoxy group, or R4 and R5 represent together a divalent alkylenedioxy group, R6 represents a hydroxy group, a methoxy group, or an acetoxy group, R7 represents a methyl group or a hydroxymethyl group, R8 represents an hydrogen atom or a hydroxy group and IMAGE represents either a IMAGE group or a IMAGE carbon atom having the double linkage in the 4- or 5-position of the steroid nucleus. Such esters are prepared by coupling reaction of the corresponding 14-azido-derivatives with a sugar, followed by a reduction. Application in therapy, especially in the treatment of heart failure.
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