首页> 外国专利> Diamidas amides and acids Omega aminoal - canoicosy diamidas alkanoic acids stituidas aromatically its Pharmaceutical compositions that contain the procedure to prepare the compuThese and the use thereof for preparing a composition for the treatment of hypertension

Diamidas amides and acids Omega aminoal - canoicosy diamidas alkanoic acids stituidas aromatically its Pharmaceutical compositions that contain the procedure to prepare the compuThese and the use thereof for preparing a composition for the treatment of hypertension

机译:Diamidas酰胺和酸ω氨基-Canoicosy diamidas链烷酸stituidas含有其制备方法的药物组合物及其在制备治疗高血压的组合物中的用途

摘要

The compound of formula (I),wherein: R1 is 2-R (A) -3-R (B) -phenyl, 2-R (A) -4-R (C) -phenyl, 2-R (A) -pyridin-3-yl, 3-R (A) -pyridin-2-yl, or a radical of 1-R (D) -indole-3-yl, where: one of R (A) and R (B) is an aliphatic or heterocycloaliphatic radical- aliphatic, or hydroxy free or aliphatically, araliphatically, or heteroaliphatically etherified, and the other is H, aliphatic or carboxy free or esterified or amidated, R (C) is H, an aliphatic radical, hydroxy free or aliphatically, araliphatically, or heteroaliphatically etherified , or an unsubstituted or heteroaliphatically substituted amino group, and R (D) is an aliphatic, araliphatic, or heteroaliphatic radical, one of X1 and X2 is carbonyl and the other is methylene,R2 is a diluent, R3 is an amino or diluent substitute, R4 is a diluent or diluent, R4 is a diluent or diluent, R5 is a propylene or cyclopropene diluent, or a heteromorphic or heteromorphic disinfectant with optional hydrogenation or / or change to oxo. Oxo and its salts linked by carbon atoms have the properties of ammonia inhibitors and can be used as drug-resistant anesthetics. This report also describes the procedures for the manufacture of these compounds and the synthesis of drugs containing them.
机译:式(I)的化合物,其中:R 1是2-R(A)-3-R(B)-苯基,2-R(A)-4-R(C)-苯基,2-R(A) -吡啶-3-基,3-R(A)-吡啶-2-基或1-R(D)-吲哚-3-基的基团,其中:R(A)和R(B)中的一个是脂族或杂环脂族基团-脂族或无羟基或脂族,芳脂族或杂脂族醚化,另一个是H,脂族或羧基无酯化或酰胺化,R(C)是H,脂族基,无羟基或R(D)为脂族,芳脂族或杂脂族基团,X1和X2之一为羰基,另一个为亚甲基,R2为稀释剂, R 3是氨基或稀释剂替代物,R 4是稀释剂或稀释剂,R 4是稀释剂或稀释剂,R 5是丙烯或环丙烯稀释剂,或具有任选氢化或/或改变为氧代的异质或异质消毒剂。通过碳原子连接的氧代及其盐具有氨抑制剂的特性,可用作抗药性麻醉药。该报告还描述了制造这些化合物以及合成含有它们的药物的程序。

著录项

  • 公开/公告号AR001774A1

    专利类型

  • 公开/公告日1997-12-10

    原文格式PDF

  • 申请/专利权人 CIBA-GEIGY A.G.;

    申请/专利号AR19950334523

  • 发明设计人

    申请日1995-12-06

  • 分类号C07C237/22;C07C237/42;C07C237/36;C07C237/08;C07D209/42;C07D401/04;C07D213/82;C07D295/13;C07D295/088;C07D295/155;C07D295/185;C07D211/46;C07D257/04;C07D295/18;C07D211/60;A61K31/165;A61K31/40;

  • 国家 AR

  • 入库时间 2022-08-22 02:58:49

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