Composed of 3 - (1,2,3,6) - tetrahidropiridin - 3 - and 4 - Ilo Ilo piperidin-4-yl) - 1H indole,5HT agonists (1F) pharmaceutical formulations containing ymetodos to activate these 5HT receptors (1F) and / or to treat migraines and disorders associated with it.

摘要

These are the novices of the fifth level HT equation (I) receiver,Where: A-B is - ch-ch2-o-c is - CH;R and R is H or alkyl: X is -SR, -C (O) R3, -C (O) NR4R15, -NR5R6, -NR7SO2R8, --NHC (Q) NR10R11, -NHC (O) OR12 or NR13C ( O) R14; where Q is O or S; R2 is substituted or non-pyridinyl phenyl; R3 is alkyl; alkylene phenyl substituted or not in phenyl, naphthyl, N-methyl-N-methoxyamino, substituted or unsubstituted heteroaryl; R4 is unsubstituted or substituted heteroaryl; R4 and R5 taken together form a pyrrolidine, piperidine, substituted piperidine, morpholino or thiomorpholine ring; R5 and R6 are both trifluoromethanesulfonyl; R7 is H or alkyl; R8 is alkyl, unsubstituted or unsubstituted phenyl, or (di alkyl) amino; R10 and R11 are alkyl, alkenyl, cycloalkyl, substituted or unsubstituted phenyl, alkyl-alkoxycarbonylalkylphenyl,C1-C4 alpha alkyl substituted with C1-C4 alkoxycarbonyl; or R10 and R11 taken together form pyrrolidine, piperidone, piperazine, 4-substituted piperazine, morpholino or thiomorpholine; R2 is alkyl, alkenyl, substituted or non-cycloalkyl phenyl, alkoxyalkyl; R13 is H or alkyl; R14 is inter alia alkyl substituted with up to 3 hydroxy, alkoxy, halo, aryloxy, alkyloxycarbonyl and heteroaryloxy, alkenyl, alkynyl, cycloalkyl, substituted or unsubstituted phenyl, naphthyl, cycloalkyl, or a heterocycle; R15 is H or alkyl; subject to when R7 is H,R8 is not a place. The 5HT receiver helps to deal with migration related problems and confusion. It is also recommended that pharmaceutical compounds made from these compounds be used as active agents for the treatment of diseases requiring activation of these receptors and / or as deoxyribonucleic acid salts for the treatment of these diseases.